Jim McAfee's Blog Spot

Monday, April 15, 2024

Cruciferous Compounds

 New Agent That Fights Lung Pathology

One of the most serious consequences of coronavirus infections results when the lungs become involved. A recent study of mice found that administration of sulforaphane, a naturally occurring compound in cruciferous vegetables, "significantly decreased the viral load in the lungs and upper respiratory tract and reduced lung injury and pulmonary pathology compared to untreated infected mice." The researchers suggested that the substance "should be explored as a potential agent for the prevention or treatment of coronavirus infections."

The antiviral activity was evident in both the test tube and also in living animals. The inflammatory response was also significantly decreased. In addition, this cruciferous compound was found to be effective against multiple coronaviruses and strains of Covid-19 including Delta and Omicron. The researchers suggest the compound be researched considered for prevention and treatment because of its safety compared to other forms of treatment. The study was conducted at Johns Hopkins University.

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Sulforaphane Bioavailable

 There is a tremendous interest in the medical community in sulforaphane and other cruciferous compounds. Sulforaphane has 80% bioavailability in one study. For comparison bioavailability of some other compounds recognized as being beneficial is limited. Quercetin has 4% bioavailability. Andrographolides have 2.67% bioavailability.

Curcumin has 1% bioavailability. Silymarin is only .73% bioavailable.
Sulforaphane significantly activates a substance called Nrf2 and as such "has the potential to modulate the expression of genes associated with redox balance, inflammation, detoxification, and antimicrobial capacity, all key components of the upstream cellular defense processes."

NeoLife long ago recognized the value of cruciferous compounds and produced Cruciferous Plus. In view of the benefits of these compounds it is a good idea to consider consuming more cruciferous vegetables and supplementing with the compounds. They support antioxidant defense by upregulating glutathione, the body's most abundant antioxidant. They also play a key role in elimination of toxins by upregulating phase-2 detoxification. They also reduce inflammation in the body and improve the ability of the immune system to deal with microbial invaders.

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