Schizophrenia and Vitamin D

     Researchers have suggested that deficiency of vitamin D during pregnancy may alter fetal development through an epigenetic mechanism leading to an increased risk of schizophrenia later on.
Schizophrenia is more common among those born in late winter and early spring when vitamin D levels of the mother tend to be lowest. At the equator schizophrenia is most common among those born after the rainy season when less sunlight is available. Children of dark-skinned migrants who move to cold climates also have greater risk of schizophrenia. Dark skin increases risk of vitamin D deficiency. Schizophrenia is also more common in cities than in rural areas.
Reference:
Mackay-Sim A, Feron F, et al, Schizophrenia, Vitamin D, and Brain Development, Int Rev Neurobiol, 2004;59:351-380.