A recent study involved supplementing 148 patients scheduled for colorectal cancer surgery with omega-3 fatty acids for 7 days prior to surgery. This was a randomized, double-blind, prospective, placebo-controlled trial. The omega-3 fatty acids reduced inflammation in the surgery patients and did not increase or decrease the risk of postoperative complications. It would appear that modest supplementation with omega-3 fatty acids is not a risk factor for surgical outcome. There is concern that excessive intake of omega-3 fatty acids prior to surgery could prolong bleeding time so I have always been cautious in this regard.
Reference:
Sorensen, L.S., et al., Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial, Nutrients, Sept. 29, 2014;6(10):4043-57.
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