Glutathione Peroxidase

     The glutathione peroxidase enzyme is the major defense of the cell against accumulation of peroxide, a highly damaging free radical. The enzyme is synthesized in response to oxidative stress experienced by the cells. The enzyme is activated by selenium. Thus one could have a great deal of the enzyme, but it remains ineffective in the absence of adequate selenium in the diet. This enzyme is also dependent upon adequate intake of sulfur-containing amino acids in the diet.