Alzheimer's as an Autoimmune Disease
A new model of Alzheimer's disease is beginning to be talked about in the medical literature. It is being suggested that the disease is autoimmune in nature and associated with infection, trauma, ischemia, and pollution. The beta amyloid associated with Alzheimer's in this model is part of the immune response of the body trying to cope with the problem rather than a causative factor in the disease. The immune system in this model attacks the neurons in the brain including the lipids which are their primary structural component.
This new model for the disease can provide some guidance with regard to prevention.
Omega-3 versus Omega-6
One of the main drivers of Alzheimer's is inflammation. The regulation of inflammation in the body is accomplished by the quality of fats in the diet. Omega-6 fats are pro-inflammatory. A diet over-weighted in these fats will run the risk of promoting or driving the development of Alzheimer's. Omega-3 fats such as salmon oil are anti-inflammatory. As a matter of fact, The resolvins and protectins which resolve the inflammatory response in such situations as trauma or infection are manufactured from the high quality omega-3 fats found in fish. A clinical trial on NeoLife Salmon Oil Plus was shown to reduce the inflammatory index by 68% in 8 weeks.
Berries and Tre
Tre is a concentrate of the anthocyanins in berries. These compounds have been noted to have a specific anti-neuroinflammatory role. Cognitive decline decreases as berry intake increases in women with Alzheimer's. Berry intake also appears to reduce the risk of developing Alzheimer's. One ounce of NeoLife Tre contains the amount of anthocyanins found in 20 ounces of pomegranate juice. The beneficial bacteria in the digestive tract increase the effectiveness of anthocyanin intake so using a product like Acidophilus Complex may also be helpful for preserving brain function.
Altered Fats and Proteins
The American diet is high in fats and proteins. Fats are often oxidized due to exposure to oxygen and long term storage. Application of high temperatures to foods alters fats and proteins. This is particularly so when high temperatures are applied to foods causing them to turn brown or black. That barbecue tastes great but many abnormal fats and proteins are produced. When these are eaten, they can become incorporated into brain tissue. When the immune system looks at these abnormal fats or proteins, it can decide to attack the cells into which these substances have become incorporated. This new model suggests this can lead to Alzheimer's.
Aluminum
Neurons can also have their structure altered by pollution. Mercury, aluminum, and lead have all been researched with regard to their ability to damage the brain. Researcher Christopher Exley, a world famous aluminum researcher, found elevated levels of aluminum in the brains of those with autism and Alzheimer's. Chapter 14 of his book is titled, "Alzheimer's Disease and the Aluminum Elephant in the Room." He concludes the chapter by writing, "I am convinced that aluminum is a cause of Alzheimer's disease and that if there were no aluminum in the brain, there would be no Alzheimer's disease within a human lifespan of at least one hundred years." Aluminum is found in cookware, baking powder, antacids, deodorants, vaccines as an adjuvant, and in many other places. Exley is particularly concerned about vaccines because this bypasses the gut barrier and delivers the aluminum directly into the bloodstream. Exley found that silicon and silicic acid (found in some water and beers) is protective against aluminum.
Mercury
A number of years ago mercury fillings were placed in the teeth of sheep and the aluminum showed up within the brain within 24 hours. The University of Calgary produced a video (see the link below) which illustrates how mercury causes brain neuron degeneration. Mercury and other heavy metals can interact with tissues in the body changing structure and resulting in autoimmune attack. The immune system looks at the cell with mercury or aluminum attached and says to itself. This is wrong and begins an attack.
Selenium is protective against mercury. A number of years ago chickens were fed mercury contaminated tuna. Scientists found that the mercury was not as toxic as expected because of the high levels of selenium in the tuna. Selenium is toxic in excess. The amount in a good multiple vitamin should be adequate to provide protection from mercury exposure in the environment.
References:
Weaver, Donald, Alzheimer’s disease as an innate autoimmune disease (AD2): A new molecular paradigm, Alzheimer’s Dement. 2023;19:1086–1098.
Henriques, Joana,F., et al., The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders, Int. J. Mol. Sci. 2020, 21, 8653
Cole, Greg M., et al., Prevention of Alzheimer’s disease: Omega-3 fatty acid and phenolic anti-oxidant interventions, Neurobiology of Aging 26S (2005) S133–S136
Exley, Christopher, Imagine You are an Aluminum Atom, New York: Skyhorse Publishing, 2020, p. 102.
Video on Mercury and Brain Neuron Degeneration
Kern, Janet k., et al., Mercury as a hapten: A review of the role of toxicant-induced brain autoantibodies in autism and possible treatment considerations, J Trace Elem Med Biol, 2020 Dec:62:126504. doi: 10.1016/j.jtemb.2020.126504. Epub 2020 May 19.